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Genomics and variation of ionotropic glutamate receptors.
Lipsky RH, Goldman D. Lipsky RH, et al. Ann N Y Acad Sci. 2003 Nov;1003:22-35. doi: 10.1196/annals.1300.003. Ann N Y Acad Sci. 2003. PMID: 14684433 Review.
A collection of 38 missense variants were identified by the informatics and resequencing approaches in several of these receptor genes, including GRIN2B, GRIN3B, GRIA2, GRIA3, and GRIK1. This represents only a fraction of the sequence variation across these genes, but, in …
A collection of 38 missense variants were identified by the informatics and resequencing approaches in several of these receptor genes, incl …
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
Takenouchi T, Hashida N, Torii C, Kosaki R, Takahashi T, Kosaki K. Takenouchi T, et al. Am J Med Genet A. 2014 Feb;164A(2):456-60. doi: 10.1002/ajmg.a.36240. Epub 2013 Nov 25. Am J Med Genet A. 2014. PMID: 24449200 Review.
Abnormal neurogenesis and neurotransmission have been implicated in the pathogenesis of these neuropsychiatric and neurodevelopmental disorders. The kainate/AMPA-type ionotropic glutamate receptor (GRIK = glutamate receptor, ionotropic, kainate) plays a critical role in sy …
Abnormal neurogenesis and neurotransmission have been implicated in the pathogenesis of these neuropsychiatric and neurodevelopmental dis …
Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction.
Mennesson M, Rydgren E, Lipina T, Sokolowska E, Kulesskaya N, Morello F, Ivakine E, Voikar V, Risbrough V, Partanen J, Hovatta I. Mennesson M, et al. Neuropsychopharmacology. 2019 Oct;44(11):1855-1866. doi: 10.1038/s41386-019-0344-5. Epub 2019 Feb 15. Neuropsychopharmacology. 2019. PMID: 30770891 Free PMC article.
Variation in KAR genes has been associated with psychiatric disorders in humans, and in mice, knockouts of the Grik1 gene have increased, while Grik2 and Grik4 knockouts have reduced anxiety-like behavior. ...
Variation in KAR genes has been associated with psychiatric disorders in humans, and in mice, knockouts of the Grik1 gene have …
[Genetic and environmental aspects of mathematical disabilities].
Kanzafarova RF, Kazantseva AV, Khusnutdinova EK. Kanzafarova RF, et al. Genetika. 2015 Mar;51(3):281-9. Genetika. 2015. PMID: 26027366 Review. Russian.
However, a large percentage of the population demonstrates mathematical disabilities. Mathematical abilities and disabilities represent a complex and multifactorial phenomenon caused by the influence of both genetic and environmental factors. ...The results of the s …
However, a large percentage of the population demonstrates mathematical disabilities. Mathematical abilities and disabilities …